Evidence map›Paper›PMID 42137799›Full record

ArticleFrontiers in microbiology2026

Taoling Yuyang Decoction alleviates DSS-induced ulcerative colitis in mice by regulating gut microbiota -metabolite axis and restore intestinal barrier function.

Dongyang Liu, Deshuang Lu, Ziwen Zhang, Chang Zhang, Shuang Liu, Jinlai Song, Xingrui Cui, Zhuoyue Dong, Lin Li, Guoying Liang and 1 more

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Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Dongyang Liu *The First Department of Gastroenterology, The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China.
Deshuang Lu *Department of Medical Technology, Qiqihar Medical University, Qiqihar, China.
Ziwen ZhangDepartment of Medical Technology, Qiqihar Medical University, Qiqihar, China.
Chang ZhangDepartment of Medical Technology, Qiqihar Medical University, Qiqihar, China.
Shuang LiuThe First Department of Gastroenterology, The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China.
Jinlai SongCollege of Basic Medicine, Heilongjiang University of Chinese Medicine, Harbin, China.
Xingrui CuiJiangsu Hospital with Integration of Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.
Zhuoyue DongDepartment of Medical Technology, Qiqihar Medical University, Qiqihar, China.
Lin LiDepartment of Medical Technology, Qiqihar Medical University, Qiqihar, China.
Guoying LiangThe First Department of Gastroenterology, The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China.
Chunjing ZhangDepartment of Medical Technology, Qiqihar Medical University, Qiqihar, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Traditional Chinese medicine (TCM) offers multi-targeted therapy with few side effects for ulcerative colitis (UC). Taoling Yuyang Decoction (TLYY) has shown clinical efficacy, however, its mechanisms of action are unclear. This study employed a multi-omics approach to elucidate TLYY's therapeutic effects in a murine DSS-induced colitis model. Methods: Using a DSS-induced mouse model of colitis, animals were divided into five groups ( Results: Taoling Yuyang Decoction treatment dose-dependently alleviated UC symptoms, including weight loss, colon shortening, and tissue damage. It enhanced antioxidant activities (SOD, GSH-Px) and reduced MDA, suppressed pro-inflammatory cytokines and LPS, and up-regulated tight junction proteins (ZO-1, Occludin, Claudin-1). Gut microbiota analysis showed TLYY-H restored microbial diversity, increased beneficial bacteria (e.g., Conclusion: Taoling Yuyang Decoction ameliorates DSS-induced colitis via integrated mechanisms involving oxidative stress reduction, anti-inflammation, intestinal barrier repair, and restoration of gut flora homeostasis and metabolic pathways. The superior effect of the high dose highlights its clinical potential for UC treatment.

Indexed as

antioxidant functiongut microbiotaintestinal barrierTaoling Yuyang Decoctionulcerative colitis

Identifiers

PMID42137799
PMCPMC13167968

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.