Evidence map›Paper›PMID 42137781›Full record

ArticleFrontiers in veterinary science2026

The origin of the double-muscle mutation in the

Yuan Xu, Caiyue Gao, Haotian Wang, Chunna Cao, Xinyue Zhang, Baohang Sun, Yilin Liang, Yuheng Bai, Yuhe Li, Yu Jiang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in veterinary science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yuan XuKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
Caiyue GaoKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
Haotian WangKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
Chunna CaoCollege of Animal Engineering, Shaanxi A&F Technology University, Key Laboratory for Efficient Ruminant Breeding Technology of Higher Education Institutions in Shaanxi Province, Yangling, Shaanxi, China.
Xinyue ZhangKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
Baohang SunKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
Yilin LiangKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
Yuheng BaiKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
Yuhe LiKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
Yu JiangKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
Ran LiKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The g.119292288G > A mutation in the 3' untranslated region (3'UTR) of the myostatin ( Methods: We analyzed whole-genome sequencing data from 73 diverse global sheep breeds to characterize the allele frequency distribution of the Results: The derived allele (A) showed a high frequency (>0.7) in East Friesian, Texel, and Dairy Meade sheep, but was rare or absent in other breeds, suggesting a likely origin in the northern Netherlands, particularly in the regions of Texel Island and Friesland Province. Selection analyses indicated that this allele experienced strong positive selection within the last ~300 years. Notably, neither the mutation nor its associated haplotype was detected in any of the ancient European samples, supporting a relatively recent emergence. In the Hu × East Friesian hybrid population, individuals carrying the mutant allele exhibited significantly greater birth weight, weaning weight, and six-month body weight compared to wild-type homozygotes ( Conclusion: Together, our results provide a comprehensive overview of the origin, spread, and phenotypic impact of the

Indexed as

ancestral recombination graphdouble-muscleevolutionary origingrowth traitssheep genomics

Identifiers

PMID42137781
PMCPMC13168175

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.