ArticleFrontiers in veterinary science2026
Single oral dose of bovine Fc-fused single-domain antibody enables multi-week serum detectability in neonatal calves.
Article in Frontiers in veterinary science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Neonatal calf diarrhea caused by bovine rotavirus (BRV) remains a major health and economic burden in cattle production, and current oral antibody approaches require frequent dosing because of poor systemic persistence. This study investigated whether a single oral dose of a BRV-specific antibody engineered with an immunoglobulin Fc region-designed to extend circulatory half-life-could be detected in the blood of newborn calves for up to 28 days. The antibody construct showed high-affinity binding to BRV antigen and effectively neutralized viral infection in cell culture. In a controlled calf trial, neonatal Holstein calves under 24 h of age (
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