ArticleCureus2026
Nodular B-Cell Cutaneous Lymphoid Infiltrate With Limited Tissue for Molecular Evaluation: A Case Highlighting Diagnostic Challenges and Management Variability.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cutaneous lymphoid infiltrates can mimic lymphoma and often present a diagnostic challenge. While gene rearrangement studies may help assess clonality, they are not always feasible in routine practice. We present a case of a nodular B-cell-predominant lymphoid infiltrate in the left proximal arm for which molecular testing could not be performed due to insufficient tissue. Histopathology and immunohistochemistry favored a reactive process, but diagnostic uncertainty remained. Management differed between providers. Dermatopathology recommended clinical monitoring, while the treating dermatologist referred the patient to hematology/oncology for further evaluation. The patient underwent a systemic workup but was ultimately lost to follow-up. This case highlights the limitations of tissue sampling, variability in management, and the importance of clinicopathologic correlation in cutaneous lymphoid infiltrates.
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