Evidence map›Paper›PMID 42137606›Full record

ArticleMolecular therapy. Advances2026

Swine reporter model for preclinical evaluation and characterization of gene delivery vectors.

Jarryd M Campbell, Derek M Korpela, Hesong Han, Sheng Zhao, Dennis A Webster, Yen Anh H Nguyen, Nicholas Koes, Robyn O Aune, Hinsoukpo Dagan, Rebecca Milliken and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Jarryd M CampbellRecombinetics, New Brighton, MN 55112, USA.
Derek M KorpelaRecombinetics, New Brighton, MN 55112, USA.
Hesong HanInnovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
Sheng ZhaoInnovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
Dennis A WebsterRecombinetics, New Brighton, MN 55112, USA.
Yen Anh H NguyenRNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Nicholas KoesRecombinetics, New Brighton, MN 55112, USA.
Robyn O AuneRecombinetics, New Brighton, MN 55112, USA.
Hinsoukpo DaganRecombinetics, New Brighton, MN 55112, USA.
Rebecca MillikenRecombinetics, New Brighton, MN 55112, USA.
Jonathan K WattsRNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Niren MurthyInnovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
Daniel F CarlsonRecombinetics, New Brighton, MN 55112, USA.

Funding

SCGE Disease Models Studies Supplement: Evaluation of prime editing for the amelioration of alpha-1-antitrypsin deficiency in murine and porcine models.U24OD026641 · OD · RECOMBINETICS, INC. · PI CARLSON, DANIEL FRED · 2018 to 2022
$4.1M
NIH HHS U24 OD026641
6 · The paper itself

Abstract

Delivery of gene therapy vectors efficiently targeted to any somatic cell remains a key barrier for the development of genetic medicines. While rodent models provide insights into vector biodistribution and cellular tropism, their anatomical and physiological differences from humans limit their translational potential and studies in large animal models are often required. In this study, we developed a swine reporter model (SRM-1) to evaluate both viral and non-viral vector delivery in a large animal system. The SRM-1 model harbors a tdTomato reporter at the

Indexed as

AAV vectorsanimal modelsbiodistributionCRISPR-Cas9gene therapymRNA deliverynon-viral gene delivery;reporterroutes of administrationswine

Identifiers

PMID42137606
PMCPMC13148913

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.