Evidence map›Paper›PMID 42137593›Full record

ArticleMolecular therapy. Advances2026

Using the nose as a factory to secrete proteins into the lungs or circulation.

Anthony Sinadinos, Robyn Bell, Claudia Ivette Juarez-Molina, Cuixiang Meng, Emily Castells, Mariana A Viegas, Deborah R Gill, Stephen C Hyde, Uta Griesenbach, Eric W F W Alton

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anthony SinadinosNational Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.
Robyn BellNational Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.
Claudia Ivette Juarez-MolinaNational Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.
Cuixiang MengNational Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.
Emily CastellsRadcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK.
Mariana A ViegasRadcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK.
Deborah R GillRadcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK.
Stephen C HydeRadcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK.
Uta GriesenbachNational Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.
Eric W F W AltonNational Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Targeting of the nasal epithelium for sustained therapeutic protein secretion represents a potential non-invasive lentiviral vector application strategy. Using reporter imaging, molecular, and radiopharmaceutical tracing methods in mice, we have developed an intranasal (nose-only) dosing strategy with a Sendai virus envelope glycoprotein pseudotyped lentiviral vector (rSIV.F/HN). Using multiple (up to 10) small-volume (5 μL) intranasal bolus applications, a technetium radiotracer showed >90% liquid retention in the murine head and <1% in the lung. Following vector administration, transgene expression was dose-related in the nose, with minimal lung expression. No acute nasal toxicity was associated with nose-only delivery. Next, we compared levels of a secreted protein,

Indexed as

gene therapylentiviral vectornosenose-as-factorypulmonary alveolar proteinosissecreted protein

Identifiers

PMID42137593
PMCPMC13144561

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.