ReviewFrontiers in pediatrics2026
Prognostic factors for pediatric sudden sensorineural hearing loss: a systematic review and meta-analysis.
Review in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
Objective: This systematic review and meta-analysis aimed to identify prognostic factors influencing hearing recovery in children with sudden sensorineural hearing loss (SSNHL), thereby providing a reference for developing prevention strategies and optimizing therapeutic interventions. Methods: We conducted a comprehensive search of PubMed, Web of Science, Cochrane Library, Embase, CNKI, and SinoMed databases to identify relevant studies published prior to 2024. Inclusion criteria encompassed pediatric patients with SSNHL (<18 years old) who had clearly documented audiological outcomes. We extracted data on demographic characteristics, clinical features, and treatment regimens to investigate the association between prognostic factors and hearing recovery. Results: This meta-analysis included 1,006 patients from 13 studies. The combined rates for partial and complete hearing recovery were 19.6% [95% confidence interval (CI): 13.6-25.7%, Conclusion: Early intervention (≤14 days) and targeted treatment for profound hearing loss (PTA > 80 dB HL) hold promise for improving pediatric outcomes. Systemic inflammatory markers (neutrophil-to-lymphocyte ratio) and age-specific pathophysiological mechanisms warrant further investigation. Conducting multicenter prospective studies is essential to validate these findings and establish standardized diagnostic and treatment protocols for pediatric SSNHL. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD42024612409, CRD42024612409.
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