ArticleFrontiers in cellular neuroscience2026
A sequential multimodal framework for spinal cord regeneration.
Article in Frontiers in cellular neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Natural Products and Neuroregeneration: Rethinking Discovery Beyond Bioavailability Through Pseudo-Natural Product Design.Biomedicines · 2026Review
- Beyond Scar Removal: Reprogramming the Glial Scar for Neural Repair.International journal of molecular sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This hypothetical study explores a potential therapeutic strategy for patients with recent complete spinal cord injuries (≤6 weeks since injury approximately). We review current literature and identify five key determinants of regenerative failure: inflammation, glial scar formation, deficit in molecular guidance, loss of structural guidance, and persistence of Wallerian debris. Although each of these barriers can be addressed by existing interventions, their efficacy depends partially on a constrained sequence of application. Based on this, a temporally orchestrated strategy is proposed, comprising early immunomodulation to stabilize the lesion environment, mechanical realignment combined with implantation of a temporary extracellular matrix to restore structural continuity, sustained molecular guidance and matrix remodeling to guide axonal growth. The proposed framework offers a mechanistically integrated and testable hypothesis for promoting functional spinal cord regeneration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.