ArticleProceedings of SPIE--the International Society for Optical Engineering2025
Interference Confocal Reflectance Microscopy for Collagen Fibril Diameter Measurement.
Article in Proceedings of SPIE--the International Society for Optical Engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Collagen fibril diameter quantification using interference confocal reflectance microscopy.Biomedical optics express · 2026Article
- On-glass Interference Confocal Reflectance Microscopy for Collagen Fibril Diameter Measurement.Proceedings of SPIE--the International Society for Optical Engineering · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Collagen fibrils provide an interesting challenge for traditional optical microscopy due to being large enough to visualize (>20nm) but usually below the Abbe diffraction limit point spread function. Confocal reflectance microscopy has been used previously to visualize collagen fibrils without fluorescent tags or other lethal methods (e.g, electron microscopy), but still cannot break the fundamental diffraction limit. We explore a sub-category of confocal reflectance known most commonly as interference reflectance microscopy, and more specifically confocal interference reflectance microscopy. The previous literature and the working principle for both mono and multi-wavelength systems are examined, finite difference time domain (FDTD) simulation results are presented, and initial imaging results of Type I collagen fibrils are shown. We believe this method has untapped potential for imaging collagen fibrils and could provide another non-lethal, no stain live imaging method to qualitatively measure collagen fibril diameters.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.