ArticleOncology letters2026
Mutational landscape in the precancerous stages of sporadic colorectal cancer.
Article in Oncology letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Colorectal adenoma (CRA) is a precancerous lesion that can progress to colorectal carcinoma (CRC); however, its malignant potential varies considerably. The present study aimed to characterize the putatively pathogenic variants (PPVs) of CRA and to assess their potential clinical relevance in identifying lesions with an increased risk of progression at precancerous stages. PPVs in a panel of 176 cancer-associated genes were analyzed in 67 CRA samples and matched adjacent normal mucosa using next-generation sequencing. The panel included genes involved in DNA repair pathways, cell cycle regulation and the genes directly associated with CRC development. PPVs in CRA tissue were identified in 44 patients. The most frequently mutated genes were found to be
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.