SynthesisFrontiers in endocrinology2026
Prevalence and determinants of recurrent laryngeal nerve injury after thyroidectomy: a Systematic Review and meta-analysis.
Synthesis in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Recurrent laryngeal nerve injury (RLNI) is a major complication of thyroid surgery and may lead to voice impairment and reduced quality-of-life. Aim: This systematic review and meta-analysis sought to determine the frequency of temporary/permanent RLNI after different types of thyroid operations and to identify surgical and patient-related factors that influence risk. Methods: PubMed, Scopus, Web of Science, Cochrane Library, and Google Scholar were searched in July 17, 2024. Eligible studies reported original data on RLNI after any type or approach of thyroidectomy in ≥20 patients. Risk of bias using RoB-2 for randomized trials and the Newcastle-Ottawa Scale for observational studies was done. Random-effects meta-analyses were performed. Subgroup and meta-regression analyses explored the effects of surgical type, method, approach, intraoperative nerve monitoring (IONM), hemostasis, drain use, and patient age on RLNI risk. Results: A total of 199 studies (304,352 patients) were analyzed. Transient RLNI was most frequent after completion thyroidectomy (10%, 95%CI, 4-16%) and hemithyroidectomy (8%, 95%CI, 1-15%), and least after near-total thyroidectomy (2%, 95%CI, 1-3%). Transoral and transcervical approaches had the highest transient RLNI rates (5%, 95%CI, 3-6%), while transaxillary had the lowest (1%, 95%CI, 1-2%). Permanent RLNI was highest in secondary thyroidectomy (2%, 95%CI, 1-3%). Meta-regression identified surgical approach, IONM use, hemostasis method, drain use, and patient age as significant determinant. Conclusions: Completion and revision surgeries, along with certain surgical approaches, increase RLNI risk. Tailoring surgical technique and optimizing intraoperative strategies are essential to minimize nerve injury. Systematic review registration: https://www.crd.york.ac.uk/prospero/, identifier CRD42024556259.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.