ArticleFrontiers in pharmacology2026
Clinical evaluation of laparoscopic repair with quadruple therapy for acute gastric ulcer perforation in elderly patients.
Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: To assess the clinical efficacy of laparoscopic gastric perforation repair combined with quadruple therapy for treating acute gastric ulcer perforation in the elderly. Method: Clinical data of 92 elderly patients with acute gastric ulcer perforation admitted to our hospital from January 2019 to May 2023 were retrospectively collected. According to the treatment they received, patients were divided into a combination group and a control group, with 46 patients in each group. The control group underwent laparoscopic gastric perforation repair alone, whereas the combination group underwent laparoscopic gastric perforation repair followed by postoperative quadruple anti- Results: Before treatment, IL-6, TNF-α, and hs-CRP levels were similar in both groups. Post-treatment, IL-6 levels in the combination group decreased to 11.89 ± 1.36 pg/mL compared to 16.23 ± 1.78 pg/mL in the control group (t = 13.14, p < 0.01); the mean difference was -4.34 (95% CI: 5.00 to -3.69), indicating a robust systemic anti-inflammatory effect. Gastric electrical parameters and serum gastrin and motilin levels increased in both groups, with better results in the combination group ( Conclusion: The results suggest that laparoscopic repair combined with quadruple therapy may effectively reduce inflammatory responses, improve gastrointestinal function, lower the incidence of early postoperative complications, and improve 6-month follow-up outcomes in elderly patients with acute gastric ulcer perforation. These findings provide a preliminary basis for the safety of this protocol in elderly patients, although validation through larger prospective randomized trials is required.
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