Evidence map›Paper›PMID 42137309›Full record

ArticleChemical science2026

Dual RONS-responsive chemiluminescence-guided multimodal thrombolysis based on an aggregation-induced emission cobalt-porphyrin nanoplatform.

Ziwei Wang, Liping Zhang, Zihan Wu, Kaijia Lin, Yachao Wang, Gelin Xu, Feng Chi, Weijin Zhu, Qianwen Liu, Dongxia Zhu and 3 more

Abstract read
In one paragraph

Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ziwei WangDepartment of Neurology, Inst Translat Med, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital Shenzhen 518035 China zhanglp914@nenu.edu.cn rlj2020@email.szu.edu.cn.ORCID https://orcid.org/0009-0004-7437-7756
Liping ZhangDepartment of Neurology, Inst Translat Med, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital Shenzhen 518035 China zhanglp914@nenu.edu.cn rlj2020@email.szu.edu.cn.ORCID https://orcid.org/0009-0003-8283-6759
Zihan WuKey Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province, Department of Chemistry, Northeast Normal University 5268 Renmin Street Changchun Jilin Province 130024 China zhudx047@nenu.edu.cn.ORCID https://orcid.org/0009-0007-0067-2623
Kaijia LinDepartment of Neurology, Inst Translat Med, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital Shenzhen 518035 China zhanglp914@nenu.edu.cn rlj2020@email.szu.edu.cn.ORCID https://orcid.org/0009-0005-5025-5452
Yachao WangDepartment of Neurology, Inst Translat Med, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital Shenzhen 518035 China zhanglp914@nenu.edu.cn rlj2020@email.szu.edu.cn.ORCID https://orcid.org/0000-0003-3709-5368
Gelin XuDepartment of Neurology, Inst Translat Med, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital Shenzhen 518035 China zhanglp914@nenu.edu.cn rlj2020@email.szu.edu.cn.ORCID https://orcid.org/0000-0002-6194-0341
Feng ChiDepartment of Neurology, Inst Translat Med, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital Shenzhen 518035 China zhanglp914@nenu.edu.cn rlj2020@email.szu.edu.cn.ORCID https://orcid.org/0009-0001-1435-1755
Weijin ZhuKey Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province, Department of Chemistry, Northeast Normal University 5268 Renmin Street Changchun Jilin Province 130024 China zhudx047@nenu.edu.cn.ORCID https://orcid.org/0009-0001-5216-1987
Qianwen LiuKey Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province, Department of Chemistry, Northeast Normal University 5268 Renmin Street Changchun Jilin Province 130024 China zhudx047@nenu.edu.cn.ORCID https://orcid.org/0009-0000-2973-8023
Dongxia ZhuKey Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province, Department of Chemistry, Northeast Normal University 5268 Renmin Street Changchun Jilin Province 130024 China zhudx047@nenu.edu.cn.ORCID https://orcid.org/0000-0003-3002-0144
Martin R BryceDepartment of Chemistry, Durham University Durham DH1 3LE UK m.r.bryce@durham.ac.uk.ORCID https://orcid.org/0000-0003-2097-7823
Ben Zhong TangSchool of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong Shenzhen Guangdong 518172 China tangbenz@cuhk.edu.cn.ORCID https://orcid.org/0000-0002-0293-964X
Lijie RenDepartment of Neurology, Inst Translat Med, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital Shenzhen 518035 China zhanglp914@nenu.edu.cn rlj2020@email.szu.edu.cn.ORCID https://orcid.org/0000-0001-5092-5616

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carotid artery thrombosis carries a high risk of disability and mortality. Organic small molecules can be used to create personalized thrombosis theranostics in precision medicine. However, due to poor water solubility, instability, and competition in energy transfer mechanisms involved in imaging and treatment, the development of small-molecule probes with efficient therapeutic performance remains challenging. Herein, we report the first bimetallic, deep-penetrating aggregation-induced emission (AIE) cobalt-porphyrin-based nanoparticles (Co2Ir NPs) that enable the simultaneous "precise targeting, accurate treatment, and effective repair" of thrombosis. Co2Ir NPs undergo dual response to reactive oxygen and nitrogen species (RONS), releasing Co2Ir, which reacts with endogenous ONOO

Identifiers

PMID42137309
PMCPMC13170895

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.