Evidence map›Paper›PMID 42137287›Full record

ArticleMolecular therapy. Advances2026

Interrogating the dependency of AAV capsids on AAVR for retinal transduction.

Valerie G Hinsch, Patrick C Kellish, Emily M Xu, Diego Fajardo, Keenan R McLaughlin, Kaitlyn N Kiel, James J Peterson, Hannah L Friend, Sanford L Boye, Shannon E Boye

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Valerie G HinschDivision of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA.
Patrick C KellishDivision of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA.
Emily M XuDivision of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA.
Diego FajardoDivision of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA.
Keenan R McLaughlinDivision of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA.
Kaitlyn N KielDivision of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA.
James J PetersonDivision of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA.
Hannah L FriendDivision of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA.
Sanford L BoyeDivision of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA.
Shannon E BoyeDivision of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA.

Funding

Engineering AAV for safe and efficient gene delivery to the human retinaR01EY024280 · NEI · UNIVERSITY OF FLORIDA · PI Shannon Elizabeth Boye · 2014 to 2026
$7.5M
NEI NIH HHS R01 EY024280
6 · The paper itself

Abstract

Adeno-associated virus (AAV) is an established vector for gene therapy, yet there remains much that we do not know regarding mechanisms of transduction in target tissues. The retina is an attractive organ for gene therapy with many programs in development. Thus, further research into the mechanisms of retinal transduction could lead to more effective therapies. Since the AAV receptor (AAVR) (KIAA0319L) has been shown to play a critical role in AAV transduction, we intravitreally injected (IVtI) or subretinally injected (SRI) recombinant AAV vectors packaged in a diverse group of AAV capsids into AAVR

Indexed as

AAVAAVRadeno-associated virusKIAA0319Locular gene therapyretina

Identifiers

PMID42137287
PMCPMC13148928

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.