Evidence map›Paper›PMID 42137282›Full record

ArticleMolecular therapy. Advances2026

Humanized mice enable

Tyler F Hill, Anna E Helmers, Rene Yu-Hong Cheng, Swati Singh, Leah J Homad, Parnal Narvekar, Gregory D Asher, Nathan D Camp, Emma R Suchland, Andee R Ott and 7 more

Abstract read
In one paragraph

Article in Molecular therapy. Advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Tyler F HillUniversity of Washington, Medical Scientist Training Program, Seattle, WA, USA.
Anna E HelmersSeattle Children's Research Institute, Center for Immunity and Immunotherapy, Seattle, WA, USA.
Rene Yu-Hong ChengSeattle Children's Research Institute, Center for Immunity and Immunotherapy, Seattle, WA, USA.
Swati SinghSeattle Children's Research Institute, Center for Immunity and Immunotherapy, Seattle, WA, USA.
Leah J HomadFred Hutchinson Cancer Center, Vaccine and Infectious Disease Division, Seattle, WA, USA.
Parnal NarvekarSeattle Children's Research Institute, Center for Immunity and Immunotherapy, Seattle, WA, USA.
Gregory D AsherSeattle Children's Research Institute, Center for Immunity and Immunotherapy, Seattle, WA, USA.
Nathan D CampSeattle Children's Research Institute, Center for Immunity and Immunotherapy, Seattle, WA, USA.
Emma R SuchlandSeattle Children's Research Institute, Center for Immunity and Immunotherapy, Seattle, WA, USA.
Andee R OttSeattle Children's Research Institute, Center for Immunity and Immunotherapy, Seattle, WA, USA.
Malika HaleSeattle Children's Research Institute, Center for Immunity and Immunotherapy, Seattle, WA, USA.
Chris D ThouvenelSeattle Children's Research Institute, Center for Immunity and Immunotherapy, Seattle, WA, USA.
Claire M StoffersSeattle Children's Research Institute, Center for Immunity and Immunotherapy, Seattle, WA, USA.
Stefan LachkarSeattle Children's Research Institute, Center for Immunity and Immunotherapy, Seattle, WA, USA.
Andrew T McGuireFred Hutchinson Cancer Center, Vaccine and Infectious Disease Division, Seattle, WA, USA.
David J RawlingsSeattle Children's Research Institute, Center for Immunity and Immunotherapy, Seattle, WA, USA.
Richard G JamesSeattle Children's Research Institute, Center for Immunity and Immunotherapy, Seattle, WA, USA.

Funding

Mechanisms mediating resistance to ibrutinib in Non-Hodgkin's lymphomaR01CA201135 · NCI · SEATTLE CHILDREN'S HOSPITAL · PI JAMES, RICHARD GOFF · 2017 to 2021
$2.1M
Developing Monoclonal Antibody Secreting Human Plasma Cells to Provide Long-Lasting EBV Immunity in Humanized MiceF30AI164574 · NIAID · UNIVERSITY OF WASHINGTON · PI HILL, TYLER F · 2021 to 2025
$171k
NCI NIH HHS R01 CA201135NIAID NIH HHS F30 AI164574
6 · The paper itself

Abstract

Engineered plasma cells (ePCs) offer a durable strategy for

Indexed as

adoptive transferantibody secretionCRISPRengineered B cellsePCsgene editinghumanized micemonoclonal antibodiesplasma cellssurface display

Identifiers

PMID42137282
PMCPMC13148940

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.