Evidence map›Paper›PMID 42137266›Full record

ArticleMolecular therapy. Advances2026

Chromophore-loaded CRALBP mutant proteins restore rod function in chromophore-deficient mice.

Alexander V Kolesnikov, Walter Aeschimann, John Cullity, Maximilian Halabi, Philip D Kiser, Achim Stocker, Vladimir J Kefalov

Abstract read
In one paragraph

Article in Molecular therapy. Advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alexander V KolesnikovGavin Herbert Eye Institute - Brunson Center for Translational Vision Research, Department of Ophthalmology and Visual Sciences, Irvine, CA 92697, USA.
Walter AeschimannDepartment of Chemistry, Biochemistry and Pharmaceutical Sciences, Freiestrasse 3, 3012 Bern, Switzerland.
John CullityNanoRetinal Inc., 41 University Drive, Suite 400, Newtown, PA 18940, USA.
Maximilian HalabiGavin Herbert Eye Institute - Brunson Center for Translational Vision Research, Department of Ophthalmology and Visual Sciences, Irvine, CA 92697, USA.
Philip D KiserGavin Herbert Eye Institute - Brunson Center for Translational Vision Research, Department of Ophthalmology and Visual Sciences, Irvine, CA 92697, USA.
Achim StockerDepartment of Chemistry, Biochemistry and Pharmaceutical Sciences, Freiestrasse 3, 3012 Bern, Switzerland.
Vladimir J KefalovGavin Herbert Eye Institute - Brunson Center for Translational Vision Research, Department of Ophthalmology and Visual Sciences, Irvine, CA 92697, USA.

Funding

NEI UCI Center Core Grant for Vision ResearchP30EY034070 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Vladimir Jivkov Kefalov · 2022 to 2026
$3.7M
Chemical Biology of the Visual PigmentsR01EY034519 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Philip David Kiser, Krzysztof Palczewski · 2023 to 2026
$2.0M
Modulation of cone photoreceptor function by autophagyR01EY035137 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Thomas Almon Ferguson, Vladimir Jivkov Kefalov · 2023 to 2026
$1.5M
BLRD VA I01 BX004939BLRD VA IK6 BX006800NEI NIH HHS P30 EY034070NEI NIH HHS R01 EY034519NEI NIH HHS R01 EY035137
6 · The paper itself

Abstract

Visual function depends critically on the supply of visual chromophore, 11-

Indexed as

CRALBPnanoparticlesopsinpigment regenerationrod photoreceptorsvisual chromophore

Identifiers

PMID42137266
PMCPMC13148898

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.