ArticleFrontiers in genetics2026
Genetic metrics decode
Article in Frontiers in genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Development of an Oxford nanopore sequencing technology-based whole genome sequencing method for Plasmodium falciparum to support malaria molecular surveillance.Scientific reports · 2026Article
- Imported malaria predominates in near-elimination settings in Southwestern Uganda.medRxiv : the preprint server for health sciences · 2026Article
- Imported malaria predominates in near-elimination settings in Southwestern Uganda.PLOS global public health · 2026Article
- Accuracy of Plasmodium falciparum genetic data for estimating parasite prevalence and malaria incidence in Uganda.Research square · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Recent evidence indicates that an increasing number of endemic countries have deployed and are using genomic surveillance to determine and monitor the trends and patterns of malaria transmission. This study aimed to evaluate and identify the most informative genetic metrics for establishing and monitoring the genetic diversity of Methods: A cross-sectional survey of symptomatic patients was conducted in 100 health facilities from February to July 2021 and covered 10 regions categorized into four strata based on transmission intensity. Parasite samples (n = 12,875) were collected as dried blood spots, and all samples with Results: The countrywide mean complexity of infection (COI) was 1.5, with 1,878 (59.6%) of parasite samples being monoclonal. The mean COI was significantly higher in high and moderate transmission strata (p < 0.001) compared to low and very low transmission strata. The odds of polyclonal infections were significantly lower in moderate, low, and very low strata compared to the high transmission stratum (p < 0.001). Parasite genetic differentiation among regions was very low, with fixation index ( Discussion: The study revealed high complexity and polyclonality, particularly in regions with high transmission intensities. The significant association between COI, polyclonality, and transmission intensity suggests these metrics can be integrated within the current malaria surveillance system and may be useful in assessing trends and patterns of malaria transmission. Further validation is needed to link these measures with the current control strategies and evaluate their use in determining the impact of different malaria interventions in Mainland Tanzania.
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Registered trials
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