Evidence map›Paper›PMID 42137230›Full record

ArticleRSC advances2026

Harnessing copper-strontium synergy in an injectable composite for multi-pathway bone regeneration.

Zhengqing Zhu, Azin Khodaei, Helen E King, Harrie Weinans, Saber Amin Yavari

Abstract read
In one paragraph

Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhengqing ZhuDepartment of Orthopedics, University Medical Center Utrecht Utrecht 3508GA The Netherlands S.AminYavari@umcutrecht.nl.ORCID https://orcid.org/0000-0002-0109-1771
Azin KhodaeiDepartment of Orthopedics, University Medical Center Utrecht Utrecht 3508GA The Netherlands S.AminYavari@umcutrecht.nl.ORCID https://orcid.org/0000-0001-8729-3296
Helen E KingMARUM, Faculty of Geosciences, University of Bremen Bremen 28359 Germany.
Harrie WeinansDepartment of Orthopedics, University Medical Center Utrecht Utrecht 3508GA The Netherlands S.AminYavari@umcutrecht.nl.
Saber Amin YavariDepartment of Orthopedics, University Medical Center Utrecht Utrecht 3508GA The Netherlands S.AminYavari@umcutrecht.nl.ORCID https://orcid.org/0000-0003-1677-5751

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone regeneration, particularly in critical-sized defects, remains a significant clinical challenge. Hydroxyapatite (HA) is widely used due to its similarity to bone mineral, yet its biological activity often requires improvement. Incorporation of therapeutic metal ions has shown promise, but the combined and mechanistically distinct effects of copper (Cu) and strontium (Sr) remain underexplored. Cu and Sr influenced stem cells

Identifiers

PMID42137230
PMCPMC13169506

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.