Evidence map›Paper›PMID 42137218›Full record

ReviewNeuro-oncology advances2026

The future of targeted therapies for pediatric central nervous system tumors.

Holly Lindsay, Eric Bouffet

Abstract readReview
In one paragraph

Review in Neuro-oncology advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Holly LindsayCenter for Cancer and Blood Disorders, Children's Hospital Colorado Anschutz Medical Campus, University of Colorado School of Medicine, Denver, Colorado, USA.
Eric BouffetHospital for Sick Children, The University of Toronto, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0002-6832-6539

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Targeted therapies are changing the landscape of pediatric brain tumor management. They offer the opportunity of more effective and personalized treatment strategies, with reduced side effects and improved outcomes. This paradigm shift in pediatric neuro-oncology is still at an early stage, and this review summarizes ongoing research that aims at finding novel drugs or at improving the management of pediatric low- and high-grade gliomas, ependymomas, embryonal tumors, germ cell tumors, craniopharyngiomas, and choroid plexus carcinomas.

Indexed as

BRAFH3K27MNTRKpediatric central nervous system tumorstargeted treatments

Identifiers

PMID42137218
PMCPMC13168769

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.