ArticleGastroenterology and hepatology from bed to bench2025
Integrative systems biology identifies
Article in Gastroenterology and hepatology from bed to bench, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aim: To identify prognostic biomarkers in colorectal cancer (CRC) using an integrative systems biology approach combining transcriptomics, network topology, and immune profiling. Background: Advanced CRC prognosis remains poor due to a lack of biomarkers capturing tumor-immune interactions. Current single-gene markers often overlook the network-based nature of tumorigenesis. Methods: We analyzed TCGA-COAD data (n = 463 tumor, n = 85 normal) using GEPIA3 with thresholds of |log_2FC| > 2 and adjusted p. value < 0.05. Protein-protein and gene-gene interaction networks were constructed via STRING (confidence > 0.4) and GeneMANIA. Hub genes were prioritized by intersecting degree and betweenness centrality using Cytoscape. Prognosis was assessed using cSurvival (Kaplan-Meier) and immune correlations via TISDB. Protein expression was verified in the Human Protein Atlas and external validation was performed to justify accuracy of candidate biomarkers. Results: Analysis revealed 992 DEGs (498 up-regulated and 494 down-regulated) enriched in extracellular matrix organization and innate immune pathways. Eight dual hub genes were identified; Conclusion:
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.