ArticleGastroenterology and hepatology from bed to bench2025
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 discriminates AGS and MKN45 cells of human gastric cancer.
Article in Gastroenterology and hepatology from bed to bench, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Aim: In the present study, differences between these cell lines are discovered via gene expression analysis. Background: Gastric cancer is a foremost health threaten worldwide with more than 650000 deaths annually. The MKN 45 cell line (the ordinary gastric mucosa) is originated from undifferentiated carcinomas, while the AGS cells display epithelial morphology and is derived from gastric adenocarcinoma. Methods: The significantly differentially expressed genes (DEGs) from the Gene Expression Omnibus (GEO) database, which discriminate AGS and MKN45 cells in the presence of DMSO and verteporfin (a chemotherapy reagent), are determined. The key DEGs were identified based on linear regression analysis and enriched to find the cellular compartment, bulk tissue gene expression, and pathways via GeneCards database. Kaplan-Meier Plot was applied to explore the percentage survival of gastric cancer patients based on the expression level of the introduced key genes. Results: About 12000 significant DEGs discriminate AGS and MKN45 cells. Procollagen-Lysine,2-oxoglutarate 5-dioxygenase 2 (PLOD2) was highlighted as the key gene among the studied significant DEGs. "Collagen chain trimerization" and "extracellular matrix organization" super-pathways, as related pathways and extracellular space and endoplasmic reticulum as the main cellular compartments were identified as the involved parts. Conclusion: MKN45 was highlighted as more invasive cancer cell relative to AGS cells. PLOD2 was pointed out as a suitable target in the chemotherapy of gastric cancer.
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