Evidence map›Paper›PMID 42137122›Full record

ArticleGastroenterology and hepatology from bed to bench2025

Characterization of three gut microbes and their toxins in cancerous and healthy tissues of Iranian patients with colorectal cancer.

Abbas Yadegar, Masoumeh Azimirad, Somayeh Jahani-Sherafat, Hadi Ahmadi Amoli, Masoumeh Farahani, Mohammad Reza Zali, Saeed Abdi, Afsaneh Sharifian

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Article in Gastroenterology and hepatology from bed to bench, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Abbas YadegarFoodborne and Waterborne Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Masoumeh AzimiradFoodborne and Waterborne Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Somayeh Jahani-SherafatLaser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Hadi Ahmadi AmoliSina Hospital, Tehran University of Medical sciences, Tehran, Iran.
Masoumeh FarahaniProteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mohammad Reza ZaliGastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Saeed AbdiGastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Afsaneh SharifianGastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim: This study aimed to investigate the presence of three gut bacteria and their toxin-encoding genes in cancerous tissues and their adjacent healthy tissues in Iranian patients with colorectal cancer (CRC). Background: CRC is a leading gastrointestinal malignancy influenced by genetic and environmental factors. Gut microbiota dysbiosis, including overgrowth of pathogenic bacteria and loss of beneficial species, contributes to carcinogenesis through toxins, inflammation, and DNA damage. Methods: Totally, 64 biopsy samples including 22 cancerous and 22 adjacent healthy tissues from CRC patients and 20 biopsy samples from healthy controls were obtained. The presence of difficile ( Results: Totally, 19 (43.2%) toxigenic Conclusion: Our study demonstrated a significant increase in

Indexed as

B. fragilisCancerous tissueC. difficileColorectal cancerETBFH. pyloriToxin genes

Identifiers

PMID42137122
PMCPMC13081416

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.