ArticleAnnual review of cancer biology2026
Impact of Chromosomal Instability and Aneuploidy in Cancer Development.
Article in Annual review of cancer biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Melanoma evolution in the lymph node shapes systemic outcomes.bioRxiv : the preprint server for biology · 2026Article
- Regulatory Roles of Kaempferol on the PI3K/AKT/mTOR Signaling Pathway and Associated MicroRNAs in Different Cancer Types.International journal of molecular sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Somatic human cells contain a diploid genome consisting of 23 pairs of chromosomes. The maintenance of this diploid state is essential across all layers of biological organization, ranging from the physiology of individual cells to the proper regulation of tissue homeostasis and organismal development. Most cancer cells, however, harbor an aneuploid genome with an abnormal number of chromosomes, including whole and/or partial chromosome gains and losses. These alterations arise as a consequence of mitotic chromosome segregation errors and/or ongoing chromosomal instability (CIN). While aneuploidy usually imposes a fitness cost to nontransformed cells, certain recurrent aneuploidies confer adaptive advantages that are subjected to positive selection throughout tumorigenesis. In this review, we discuss how aneuploidy impacts cellular physiology, fitness, and adaptability in the context of cancer development. We also examine how the aneuploid state and CIN can create vulnerabilities that may be exploited for therapeutic intervention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.