ArticleHuman mutation2026
Role of Macrophage-Related Genes GAS7 and ZEB2 in Acute Myocardial Infarction Pathogenesis.
Article in Human mutation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Role of Macrophage-Related Genes GAS7 and ZEB2 in Acute Myocardial Infarction Pathogenesis.Human mutation · 2026Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Acute myocardial infarction (AMI) involves complex immune responses and cellular interaction mechanisms. Although the pathogenesis of AMI is now preliminarily understood, there is still a lack of biomarkers that can accurately and rapidly diagnose its disease characteristics. Methods: This study analyzed single-cell RNA sequencing (scRNA-seq) and bulk RNA-seq data related to AMI from the Gene Expression Omnibus (GEO) database. Data preprocessing and clustering were performed using Seurat, and cell-cell communication was analyzed using CellChat. Functional enrichment was performed using clusterProfiler. Key transcription factors were identified using SCENIC, and module-specific genes associated with macrophages in AMI were identified using high-dimensional weighted gene coexpression network analysis (hdWGCNA). These were combined with WGCNA to identify genes associated with AMI. Molecular docking was then used to predict potential targeted drugs for AMI. In addition, an oxygen-glucose deprivation (OGD)-induced AC16 cardiomyocyte model combined with quantitative real-time polymerase chain reaction (qRT-PCR) was used to validate the expression patterns of the key regulators and biomarkers. Results: This study identified six cell types in AMI, including adipocytes, cardiomyocytes, endothelial cells, fibroblasts, macrophages, and smooth muscle cells. CellChat showed that cell-cell communication intensity was generally enhanced in AMI. hdWGCNA identified the M5 and M8 modules as significantly associated with macrophages. SCENIC analysis found that Conclusion: This study revealed the cellular communication characteristics in the pathogenesis of AMI and identified
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