ArticleACG case reports journal2026
Severe Cryptosporidiosis Following Tumor-Infiltrating Lymphocyte Therapy in a Patient With Metastatic Mucosal Melanoma.
Article in ACG case reports journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
Cryptosporidium is a protozoan parasite that can cause respiratory and gastrointestinal illnesses with watery diarrhea. Severe disease may occur in immunocompromised patients, especially those with acquired immunodeficiency syndrome or metastatic mucosal melanoma on immunosuppressive therapy. We report a 72-year-old man with metastatic mucosal melanoma treated with surgery, radiation, and tumor-infiltrating lymphocytes therapy complicated by hemophagocytic lymphohistiocytosis and autoimmune colitis. He presented with an acute profuse diarrhea despite sulfasalazine and budesonide therapy for his colitis. Intestinal biopsy confirmed Cryptosporidium parvum. Although uncommon, cryptosporidial infection should be suspected in immunocompromised patients with persistent diarrhea. Diagnosis is via stool microscopy, polymerase chain reaction, or enzyme immunoassay.
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