ArticleEuropean heart journal. Imaging methods and practice2026
The predictive value of left atrioventricular coupling index for ILR-detected atrial fibrillation following an embolic stroke of undetermined source in patients with sinus rhythm.
Article in European heart journal. Imaging methods and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The prediction of atrial fibrillation in high-risk populations is an important research area of modern atrial fibrillation care. One such population is the embolic stroke of undetermined source population, where appropriate anticoagulation might help reduce the annual stroke recurrence risk by 5%. In this study, individuals were categorized according to their tertile of left atrioventricular coupling index, a composite echocardiographic parameter that reflects both left atrial and ventricular size. Its association with the detection of an implantable loop recorder and subclinical atrial fibrillation was investigated. A retrospective single-centre cohort study was performed. A total of 296 embolic stroke of undetermined source patients, referred for an implantable loop recorder, who also underwent echocardiography, were screened. Of these, 230 cases had echocardiograms of sufficient quality to measure the left atrioventricular coupling index. Patients were categorized according to their left atrioventricular coupling index tertile, with tertile 1 being less than 16.97, tertile 2 being 16.97-23.9, and tertile 3 being greater than 23.9. Patients in the third left atrioventricular coupling tertile were more likely to develop atrial fibrillation of any duration, with a 1.9-fold increased univariable hazard ratio, although this association was not significant in longer duration of atrial fibrillation episode. This effect was no longer significant with stepwise multivariable analysis, suggesting that age was primarily mediating the effect seen in this study. Left atrioventricular coupling index was not an independent predictor of future implantable loop recorder-detected atrial fibrillation after adjustment for age in this cohort.
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