ArticleFrontiers in medicine2026
Rapidly progressive Hodgkin lymphoma causing superior vena cava syndrome in late pregnancy: a case report and literature review.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Hodgkin lymphoma during pregnancy is rare and may present diagnostic and therapeutic challenges, particularly when complicated by superior vena cava syndrome, a life-threatening condition. We report a 41-year-old pregnant patient at 30 weeks of gestation who presented with rapidly progressive dyspnea, cervical venous congestion, and facial edema. Imaging revealed a bulky mediastinal mass compressing the superior vena cava. Due to acute maternal risk, an emergency multidisciplinary decision was made to perform cesarean delivery followed by immediate uniportal video-assisted thoracoscopic biopsy. Histopathology confirmed classical Hodgkin lymphoma, nodular sclerosis subtype. Postpartum positron emission tomography/computed tomography demonstrated extensive supradiaphragmatic disease, and chemotherapy with doxorubicin, bleomycin, vinblastine, and dacarbazine was promptly initiated. The patient showed a favorable clinical and metabolic response, and the neonate demonstrated normal early postnatal development. This case highlights the importance of early recognition and multidisciplinary management of superior vena cava syndrome in pregnancy and raises the hypothesis that pregnancy-associated immunologic changes, including interleukin-6-mediated pathways, may contribute to accelerated disease progression.
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