SynthesisFrontiers in medicine2026
Risk factors for drug-induced liver injury in tuberculosis patients: a meta-analysis and systematic review.
Synthesis in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic review and meta-analysis of risk prediction models for anti-tuberculosis drug-induced liver injury in East Asian populations.Frontiers in public health · 2026Pooled it
- HBV/HCV coinfection and anti-tuberculosis drug-induced liver injury: from risk assessment and exploration of mechanisms to preventive considerations.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: A meta-analysis and systematic review of risk factors for drug-induced liver injury in tuberculosis patients. Methods: Computerized searches were conducted in PubMed, Embase, Web of Science, and the Cochrane Library databases to identify studies investigating risk factors for drug-induced liver injury in tuberculosis patients. The search period spanned from the inception of each database to January 2026. Two researchers independently screened studies, extracted data, and assessed risk of bias in included studies. Meta-analysis was performed using Stata 15.0 software. Results: A total of 41 studies involving 34,251 subjects were included. Meta-analysis revealed that female gender [OR = 1.35, 95% CI (1.05, 1.73)], alcohol consumption [OR = 2.07, 95% CI (1.57, 2.72)], extrapulmonary tuberculosis [OR = 2.01, 95% CI (1.66, 2.44)], disseminated TB [OR = 1.74, 95% CI (1.18, 2.59)], albumin <35 g/L [OR = 2.16, 95% CI (1.52, 3.06)], Malnutrition [OR = 3.32, 95% CI (1.52, 7.24)], HIV [OR = 1.80, 95% CI (1.09, 2.99)], HCV [OR = 2.17, 95% CI (1.10, 4.29)], hepatotoxic drugs [OR = 2.65, 95% CI (1.58, 4.43)] may constitute risk factors for drug-induced liver injury in tuberculosis patients. Conclusion: Female gender, alcohol consumption, extrapulmonary tuberculosis, disseminated tuberculosis, serum albumin levels below 35 g/L, malnutrition, HIV infection, HBsAg positivity, HCV infection, and hepatotoxic drugs may constitute risk factors for drug-induced liver injury in tuberculosis patients. Given limitations in the number and quality of included studies, these findings require validation through further high-quality research. Systematic review registration: This study has been registered on the PROSPERO platform, registration number: CRD420261302758.
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