ArticleFrontiers in medicine2026
The predictive value of the Systemic Inflammatory Response Index in evaluating the severity of influenza A-induced viral pneumonia among elderly patients: a retrospective analysis.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Influenza A virus (IAV) pneumonia poses a significant threat to the elderly, often leading to severe outcomes due to age-related immunological decline. Early and accurate assessments of disease severity is critical for improving clinical management and prognosis. The Systemic Inflammatory Response Index (SIRI), which integrates neutrophil, monocyte, and lymphocyte counts, may serve as a novel biomarker to reflect the systemic inflammatory state and predict disease progression in older adults. Methods: A retrospective analysis was conducted involving 160 patients aged 65 years or older who were diagnosed with IAV pneumonia at China Resources Wuhan Iron and Steel General Hospital between December 2024 and March 2025. Patients were categorized into favorable (CURB-65 [confusion, urea, respiratory rate, blood pressure, age ≥ 65 years] score <3, Results: SIRI levels were significantly higher in the unfavorable prognosis group than in the favorable prognosis group ( Conclusion: The SIRI is a reliable and objective biomarker for assessing disease severity and predicting prognosis in elderly patients with IAV pneumonia. Its use may facilitate early identification of high-risk individuals, guide timely clinical intervention, and ultimately improve patient outcomes.
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