ArticleFrontiers in medicine2026
A three-factor nomogram predicts the use of invasive mechanical ventilation within 72 h in preterm infants.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Early identification of preterm infants at risk for invasive mechanical ventilation (IMV) enables timely respiratory support and may reduce ventilation-related harm. Objective: To develop and internally validate a parsimonious prediction model for IMV within 72 h after birth. Methods: We conducted a single-center retrospective cohort study (July 2023-June 2024) including 1,059 preterm infants admitted within 72 h of life and randomly split them into training ( Results: In the validation set, the model achieved an AUC of 0.816; at the optimal probability threshold (0.224), sensitivity, specificity, and accuracy were 0.613, 0.914, and 0.855, respectively. Calibration was good (Brier score 0.096; Hosmer-Lemeshow Conclusion: A three-factor model based on perinatal and early neonatal indicators provides accurate, well-calibrated prediction of IMV within 72 h and is readily implementable for bedside risk stratification; external validation is warranted.
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