Intracytoplasmic sperm injection for non-male factor infertility does not improve cumulative live birth rate: a Canadian assisted reproductive technologies registry (CARTR Plus) descriptive study.

Z M Ferraro, L Meng, K E Liu, E M Greenblatt, M A Russo

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Article in Frontiers in reproductive health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

Authors and funding

5 authors.

Z M FerraroDepartment of Obstetrics and Gynaecology, University of Toronto, Toronto, Ontario, Canada.

L MengBetter Outcomes Registry & Network (BORN), Centre for Practice-Changing Research Building, Ottawa, Ontario, Canada.

K E LiuDepartment of Obstetrics and Gynaecology, University of Toronto, Toronto, Ontario, Canada.

E M GreenblattDepartment of Obstetrics and Gynaecology, University of Toronto, Toronto, Ontario, Canada.

M A RussoDepartment of Obstetrics and Gynaecology, University of Toronto, Toronto, Ontario, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To determine whether intracytoplasmic sperm injection (ICSI) improves cumulative live birth rates (cLBR) compared with conventional IVF among patients with non-male factor infertility. Methods: This descriptive retrospective cohort study used linked Canadian Assisted Reproductive Technologies Registry (CARTR Plus) and Better Outcomes Registry & Network (BORN) data from 2013 to 2022. Outcomes were compared by insemination technique (IVF vs. ICSI). The primary outcome was cLBR per retrieval; secondary outcomes included normal fertilization (2PN), fertilization rate, utilizable embryos per retrieval, and cycles without live birth. Results: Among 140,252 retrieval cycles (35,251 IVF; 105,001 ICSI), cLBR was higher with conventional IVF (38.5% vs. 36.3%, Conclusions: In non-male factor infertility, ICSI does not improve cumulative live birth outcomes compared with conventional IVF.

Indexed as

cumulative live birth ratefertilization rateICSIIVFnon-male factor infertility

Identifiers

PMID42136823

DOI10.3389/frph.2026.1822305

PMCPMC13168045

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