Evidence map›Paper›PMID 42136817›Full record

ReviewFrontiers in systems biology2026

AI-based methods for the assessment of DNA damage and repair mechanisms.

Paola Lecca, Michela Lecca, Adaoha Elizabeth Ihekwaba-Ndibe

Abstract readReview
In one paragraph

Review in Frontiers in systems biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Paola LeccaFaculty of Engineering, Free University of Bozen-Bolzano, Bolzano-Bozen, Italy.
Michela LeccaTechnologies of Vision Unit at Digital Industry Center, Fondazione Bruno Kessler, Trento, Italy.
Adaoha Elizabeth Ihekwaba-NdibeSchool of Sciences, Coventry University, Coventry, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, a growing number of artificial intelligence (AI)-driven approaches have been developed to elucidate chemico-biological interactions associated with DNA damage and oxidative stress. Deep learning-based techniques, in particular, have demonstrated substantial potential within molecular biology and toxicology. As a result, researchers and clinicians alike hold high expectations that AI-enabled tools will soon make meaningful contributions to our understanding of the molecular and cellular mechanisms governing DNA damage and repair. In this article, we present a concise yet comprehensive overview of the computational methodologies underpinning contemporary deep learning approaches. We examine their capacity to support DNA damage assessment by revealing mechanistic insights into damage induction and response pathways. Particular emphasis is placed on deep learning techniques designed to enhance the analysis of complex biological data, including the automated detection and quantification of DNA damage from

Indexed as

Bayesian artificial neural networkscomet assaydeterministic artificial neural networksDNA repairrecurrent neural networks

Identifiers

PMID42136817
PMCPMC13167429

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.