ArticleFrontiers in neurology
Development of an automated machine learning-based prediction model and interactive tool for blood transfusion requirements in patients with severe traumatic brain injury.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To develop an AutoML-based interpretable prediction model for blood transfusion requirements in severe traumatic brain injury (sTBI) patients, optimizing blood resource management through clinical-translational tools. Methods: In this retrospective cohort study (January 2020-January 2025), 638 sTBI patients were enrolled. Random stratified sampling divided data into training ( Results: The AutoML model demonstrated exceptional performance in the independent testing set, with ROC-AUC and PR-AUC values reflecting high predictive accuracy. It consistently outperformed comparator models across all metrics, including F1-score (0.8387), while DCA confirmed superior net benefit across clinically relevant thresholds. SHAP analysis identified nine key predictors hierarchically influencing transfusion risk: treatment type, GCS score, INR, K Conclusion: This explainable AutoML framework successfully deciphers multidimensional determinants of sTBI transfusion needs. The clinically deployable interactive system eliminates technical barriers through intuitive nine-feature input, establishing new paradigm for trauma care decision-support and blood resource optimization.
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