Evidence map›Paper›PMID 42136796›Full record

ArticleOpen medicine (Warsaw, Poland)2026

Hypertonic thermal solutions as a putative strategy for respiratory biofilm disruption.

Marilina Falcone, Laura Pietrangelo, Antonio Guarnieri, Natasha Brancazio, Noemi Venditti, Maria Di Naro, Giulio Petronio Petronio, Roberto Di Marco, Attilio Varricchio

Abstract read
In one paragraph

Article in Open medicine (Warsaw, Poland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Marilina FalconeDepartment of Medicina e Scienze della Salute "V. Tiberio", Università degli Studi del Molise, Campobasso, Molise, Italy.ORCID https://orcid.org/0009-0009-7277-1377
Laura PietrangeloDepartment of Medicina e Scienze della Salute "V. Tiberio", Università degli Studi del Molise, Campobasso, Molise, Italy.ORCID https://orcid.org/0000-0001-7636-5581
Antonio GuarnieriDepartment of Medicina e Scienze della Salute "V. Tiberio", Università degli Studi del Molise, Campobasso, Molise, Italy.ORCID https://orcid.org/0000-0003-3949-4143
Natasha BrancazioDepartment of Medicina e Scienze della Salute "V. Tiberio", Università degli Studi del Molise, Campobasso, Molise, Italy.ORCID https://orcid.org/0009-0001-2203-3327
Noemi VendittiResponsible Research Hospital, UO Laboratorio Analisi, Campobasso, Molise, Italy.ORCID https://orcid.org/0000-0003-4952-1889
Maria Di NaroDepartment of Medicina e Scienze della Salute "V. Tiberio", Università degli Studi del Molise, Campobasso, Molise, Italy.ORCID https://orcid.org/0009-0002-0116-0308
Giulio Petronio PetronioDepartment of Medicina e Scienze della Salute "V. Tiberio", Università degli Studi del Molise, Campobasso, Molise, Italy.ORCID https://orcid.org/0000-0002-5098-7785
Roberto Di MarcoConsorzio Interuniversitario per l'Ingegneria e la Medicina (CoIIM), Campobasso, Molise, Italy.ORCID https://orcid.org/0000-0001-5075-4597
Attilio VarricchioDepartment of Medicina e Scienze della Salute "V. Tiberio", Università degli Studi del Molise, Campobasso, Molise, Italy.ORCID https://orcid.org/0000-0002-6208-4129

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Upper respiratory tract infections pose a significant challenge for healthcare systems worldwide. Forming biofilms-complex polymicrobial communities encased in an exopolymer matrix plays a pivotal role in the persistence of these infections, contributing to enhanced resistance against conventional treatments and host immune responses. Consequently, developing innovative strategies to disrupt biofilms has become a therapeutic imperative.This study investigated the Methods: Biofilm formation by Results: A significant, concentration-dependent reduction in biofilm biomass was observed in all tested microorganisms when treated with the hypertonic solution. This effect was also evident in polymicrobial biofilms, indicating a broad and consistent antibiofilm potential. Conclusions: The hypertonic solution of salsobromoiodic thermal water demonstrated notable

Indexed as

biofilmshypertonic solutionrespiratory tract infectionsthermal water

Identifiers

PMID42136796
PMCPMC13170976

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.