ReviewFrontiers in cardiovascular medicine2026
Are clinical trajectories in obstructive hypertrophic cardiomyopathy mutation-specific? A systematic review and meta-analysis of
Review in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The clinical course of obstructive hypertrophic cardiomyopathy (HCM) is highly variable. Whether this heterogeneity reflects mutation-specific clinical trajectories remains a pivotal question for prognostication and personalized management. Objectives: This study aimed to determine if pathogenic sarcomeric variants in Methods: We conducted a systematic review and meta-analysis following PRISMA 2020 guidelines. Four databases were searched up to October 2025 for cohort or registry studies reporting on sarcomeric variants and quantitative phenotypes in obstructive HCM. Data were extracted independently in duplicate, and effect estimates were pooled as odds ratios (OR), mean differences (MD), or hazard ratios (HR) with 95% confidence intervals (CI). Results: Ten studies comprising 192,361 participants were included, encompassing a large population sequencing cohort (UK Biobank/Mass General Brigham) of 184,511 and nine clinical/registry cohorts totaling 7,850. Carriers of Conclusions: This analysis confirms that obstructive HCM follows mutation-specific clinical trajectories. Genotype provides critical prognostic insights, delineating an
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