ArticleFrontiers in cardiovascular medicine2026
Differential expression of GLP1R, PCSK9, and SGLT2 in human aortic versus mitral valve tissues: exploratory findings in calcific aortic valve disease.
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Calcific aortic valve disease (CAVD) is a common valvular heart disorder for which effective pharmacological treatments remain lacking. This study aimed to compare the expression and potential pathophysiological relevance of glucagon-like peptide-1 receptor (GLP1R), proprotein convertase subtilisin/kexin type 9 (PCSK9), and sodium-glucose cotransporter 2 (SGLT2) in human aortic valve (AV) and mitral valve (MV) tissues from patients undergoing valve replacement surgery. Methods: Surgically resected AV ( Results: GLP1R, PCSK9, and SGLT2 expression levels were significantly elevated in AV tissues compared to MV tissues (all Conclusion: These findings reflect differential expression between anatomically distinct valve types and do not establish CAVD-specific upregulation.
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