Evidence map›Paper›PMID 42136714›Full record

ArticleFrontiers in cardiovascular medicine2026

A cost-effective proof-of-concept

Sainath P, Shakta Mani Satyam, Abdul Rehman, Sanjay Bharati, Prakashchandra Shetty, Mohamed El-Tanani, Akheruz Zaman Ahmed, Rashmi Kumari, Muaweya Sufian Albadawi, Firas Assaf and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Sainath PDepartment of Perfusion Technology, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, India.
Shakta Mani SatyamDepartment of Pharmacology, RAK College of Medical Sciences, RAK Medical and Health Science University, Ras al Khaimah, United Arab Emirates.
Abdul RehmanDepartment of Pathological Sciences, College of Medicine, Ajman University, Ajman, United Arab Emirates.
Sanjay BharatiDepartment of Nuclear Medicine, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, India.
Prakashchandra ShettyDepartment of Anatomy, Manipal University College Malaysia, Melaka, Malaysia.
Mohamed El-TananiRAK College of Pharmacy, RAK Medical and Health Science University, Ras al Khaimah, United Arab Emirates.
Akheruz Zaman AhmedDepartment of Anatomy, Fakhruddin Ali Ahmed Medical College, Srimanta Sankaradeva University of Health Sciences, Assam, India.
Rashmi KumariA. J. Institute of Hospital Management, Mangalore, India.
Muaweya Sufian AlbadawiDepartment of Pharmacology, RAK College of Medical Sciences, RAK Medical and Health Science University, Ras al Khaimah, United Arab Emirates.
Firas AssafDepartment of Pharmacology, RAK College of Medical Sciences, RAK Medical and Health Science University, Ras al Khaimah, United Arab Emirates.
Seyed Mohammad Seyed Morteza HashemiDepartment of Pharmacology, RAK College of Medical Sciences, RAK Medical and Health Science University, Ras al Khaimah, United Arab Emirates.
Faisal Aslam KhanDepartment of Pharmacology, RAK College of Medical Sciences, RAK Medical and Health Science University, Ras al Khaimah, United Arab Emirates.
Mohmed Krem Adnan DoukarliDepartment of Pharmacology, RAK College of Medical Sciences, RAK Medical and Health Science University, Ras al Khaimah, United Arab Emirates.
Marwan Mohamed Hassan Rustom RobariDepartment of Pharmacology, RAK College of Medical Sciences, RAK Medical and Health Science University, Ras al Khaimah, United Arab Emirates.
Murk Jai Pal ParyaniDepartment of Pharmacology, RAK College of Medical Sciences, RAK Medical and Health Science University, Ras al Khaimah, United Arab Emirates.
Varun Kumar SinghNational Reference Lab, Redcliffe Labs, Noida, Uttar Pradesh, India.
Ganesh Kamath SDepartment of Cardiovascular and Thoracic Surgery, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Myocardial ischemia-reperfusion injury (IRI) continues to impede the advancement of effective cardioprotective therapies. Experimental limitations, particularly the lack of accessible and cost-effective Methods: Twelve adult male Wistar rats were randomly assigned to a non-ischemic control group ( Results: The IRI group demonstrated an approximately 4.7-fold reduction in coronary flow during early reperfusion, reflecting acute vascular dysfunction. TTC staining revealed significant infarct development compared to controls. Histopathological examination confirmed cardiomyocyte degeneration, cytoplasmic vacuolization, inflammatory cell infiltration, and interstitial edema. Functional impairment strongly correlated with structural myocardial injury, demonstrating consistent induction of myocardial injury within the experimental setting. Discussion: This simplified

Indexed as

cardioprotective researchex-vivo heart perfusionischemic heart disease modellangendorff modelmyocardial ischemia-reperfusion injurypreclinical cardiovascular modelTTC staining

Identifiers

PMID42136714
PMCPMC13167710

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.