ReviewFrontiers in immunology2026
Multiple roles of MicroRNAs in melanoma: biomarkers for diagnosis, prognosis, and treatment prediction.
Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
4 authors.
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Abstract
Melanoma, a highly malignant form of skin cancer, continues to rise in incidence worldwide. Early diagnosis and accurate prognostic assessment are critical to reducing melanoma-related mortality rates. MicroRNAs (miRNAs), a class of non-coding RNAs approximately 22 nucleotides in length, play pivotal roles in melanoma initiation, progression, invasion, and metastasis by regulating the expression of target genes. Beyond their cell-intrinsic functions, miRNAs are increasingly recognized as critical regulators of the tumor immune microenvironment (TIME). They modulate anti-tumor immune responses by influencing immune checkpoint expression, immune cell recruitment and function, and intercellular communication via extracellular vesicles (EVs). This comprehensive review explores the multifaceted functions of miRNAs in melanoma, highlighting their potential as diagnostic markers, prognostic indicators, and predictors of therapeutic response. It also addresses current research challenges and explores future directions, including the integration of AI-powered spatial transcriptomics to decipher the complex, context-dependent networks of miRNAs within the TIME, offering a theoretical foundation and novel insights for precision medicine in melanoma treatment.
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