ArticleFrontiers in immunology2026
Case Report: A hidden cause of severe hemorrhage: a diagnostic and therapeutic challenge.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Acquired factor XIII (FXIII) deficiency is a rare but life-threatening cause of hemorrhagic diseases. We report a case of a patient presenting with life-threatening bleeding with normal routine coagulation tests. The diagnosis was confirmed by a specific FXIII activity assay. The subsequent absence of ANA delayed the definitive diagnosis, which was ultimately established as ANA-negative systemic lupus erythematosus (SLE) based on comprehensive clinical criteria and multisystem involvement. This case presented a profound diagnostic dilemma, requiring not only the identification of a rare acquired FXIII deficiency as the cause of unexplained bleeding, but also the confirmation of SLE despite seronegativity, relying on its multisystem manifestations.
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