Evidence map›Paper›PMID 42136635›Full record

ArticleFrontiers in immunology2026

Immature CD10

Luke W Garratt, Alice A White, Craig Schofield, Jonatan Leffler, Prue H Hart, Marzena J Fabis-Pedrini, Allan G Kermode, Anne Brüstle, Stephanie Trend

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Luke W Garratt *Wal-Yan Respiratory Research Centre, The Kids Research Institute Australia, Perth, WA, Australia.
Alice A White *Translational Immunology Team, The Kids Research Institute Australia, Perth, WA, Australia.
Craig SchofieldWal-Yan Respiratory Research Centre, The Kids Research Institute Australia, Perth, WA, Australia.
Jonatan LefflerWal-Yan Respiratory Research Centre, The Kids Research Institute Australia, Perth, WA, Australia.
Prue H HartTranslational Immunology Team, The Kids Research Institute Australia, Perth, WA, Australia.
Marzena J Fabis-PedriniDemyelinating Diseases Research Group, Perron Institute for Neurological and Translational Science, University of Western Australia, Perth, WA, Australia.
Allan G KermodeDemyelinating Diseases Research Group, Perron Institute for Neurological and Translational Science, University of Western Australia, Perth, WA, Australia.
Anne BrüstleJohn Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia.
Stephanie TrendTranslational Immunology Team, The Kids Research Institute Australia, Perth, WA, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Neutrophils are proposed to contribute to inflammation at the onset of multiple sclerosis (MS). However, as neutrophils must be analysed rapidly following blood collection, their characterisation remains challenging, and the biology of neutrophils during episodes of MS is poorly understood. Neutrophils can comprise of several subpopulations and diverse phenotypes that are modified across health states and tissues. We hypothesised that neutrophil subpopulations would significantly differ in abundance between people with MS and controls. Method: Our pilot study applied flow cytometry to analyse phenotypes of neutrophils present in the peripheral blood of 10 people with recently active MS or clinically isolated syndrome (CIS) and 12 control participants. Results: Using both unsupervised and supervised analyses of flow cytometry data, we identified that CD10 Discussion: These findings point to immature CD10

Indexed as

Multiple SclerosisNeprilysinNeutrophilsAdultBiomarkersCase-Control StudiesFemaleFlow CytometryHumansImmunophenotypingMaleMiddle AgedPilot ProjectsBiomarkersNeprilysinCD10flow cytometrymultiple sclerosisneutrophilpathogenesis

Identifiers

PMID42136635
PMCPMC13167547

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.