Evidence map›Paper›PMID 42136610›Full record

Observational studyFrontiers in public health2026

Occupational tobacco exposure and multisystem morbidity among beedi rollers: biomarker-validated evidence from a multi-state study in India.

Rakesh Kakkar, Om Prakash Bera, Joanna E Cohen, Vandana Shah, Monica Kakkar, Sejal Saraf, Surekha Kishore, Sonu Hangma Subba, Chetna Maliye, Darivemula Surendra Babu and 14 more

Abstract readMulticenter StudyObservational Study
In one paragraph

Observational study in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Rakesh KakkarDepartment of Community and Family Medicine, All India Institute of Medical Sciences, Bathinda, Punjab, India.
Om Prakash BeraGlobal Health Advocacy Incubator, Washington, DC, United States.
Joanna E CohenJohns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.
Vandana ShahGlobal Health Advocacy Incubator, Washington, DC, United States.
Monica KakkarDepartment of Biochemistry, All India Institute of Medical Sciences, Bathinda, Punjab, India.
Sejal SarafJohns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.
Surekha KishoreDepartment of Community and Family Medicine, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
Sonu Hangma SubbaDepartment of Community Medicine and Family Medicine, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.
Chetna MaliyeDepartment of Community Medicine, Mahatma Gandhi Institute of Medical Sciences, Sewagram, Maharashtra, India.
Darivemula Surendra BabuDepartment of Community Medicine, Employees' State Insurance Corporation Medical College, Sanathnagar, Hyderabad, Telangana, India.
Kusum GaurDepartment of Community Medicine, SMS Medical College, Jaipur, India.
Soumya Swaroop SahooDepartment of Community and Family Medicine, All India Institute of Medical Sciences, Bathinda, Punjab, India.
Madhur VermaDepartment of Community and Family Medicine, All India Institute of Medical Sciences, Bathinda, Punjab, India.
U VenkateshDepartment of Community and Family Medicine, All India Institute of Medical Sciences, Gorakhpur, Uttar Pradesh, India.
Binod Kumar BeheraDepartment of Community Medicine and Family Medicine, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.
Manish TaywadeDepartment of Community Medicine and Family Medicine, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.
Amey DhatrakDepartment of Community Medicine, Mahatma Gandhi Institute of Medical Sciences, Sewagram, Maharashtra, India.
Badal Chandrakant BhandarkarDepartment of Community Medicine, Government Medical College, Nagpur, Maharashtra, India.
Mohnish Yuvrajgir GiriTaluka Health Office, Chimur, Maharashtra, India.
Varkey Nadakkavukaran SanthoshDepartment of Community and Family Medicine, All India Institute of Medical Sciences, Gorakhpur, Uttar Pradesh, India.
Jaspreet Kaur PalCampaign for Tobacco-Free Kids, Washington, DC, United States.
Radhika KhajuriaCampaign for Tobacco-Free Kids, Washington, DC, United States.
Ranjit SinghSupreme Court of India, New Delhi, India.
Krupal JoshiDepartment of Community and Family Medicine, All India Institute of Medical Sciences, Rajkot, Gujarat, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Beedi rolling, employing nearly five million predominantly female home-based workers across India, remains one of the less formally organized occupational sectors. This study aimed to evaluate the working conditions and health hazards of beedi rollers across five Indian states. Methods: A multi-centric cross-sectional study conducted in five states enrolled 1,800 adults; 900 beedi rollers and 900 controls. Data were obtained through structured interviews, clinical examinations, spirometry, and biochemical analyses of blood and urine samples. A multivariable binary logistic regression model was used to quantify the adjusted associations between occupational status (beedi rollers vs. non-beedi workers) and various morbidities, accounting for sociodemographic confounders. Results: Beedi rollers had significantly higher odds of musculoskeletal and exposure-related conditions. Adjusted odds ratios for neck pain, back and leg pain, and lower back pain were 5.77, 3.14, and 1.71, respectively. Respiratory and ocular symptoms were more prevalent, with sneezing (AOR 3.13) and ocular redness (AOR 2.19) markedly elevated. Mean urinary cotinine levels were substantially higher among exposed workers (76.97 ng/ml) compared to controls (15.81 ng/ml; Conclusion: This multi-state analysis underscores the profound occupational health burden among beedi rollers, driven by ergonomic strain and chronic tobacco exposure. Despite being a large informal workforce, these workers have yet to be fully integrated into occupational health services, highlighting opportunities to strengthen India's progress toward Universal Health Coverage. Addressing these gaps calls for strengthening workplace design, reinforcing occupational safety standards, and implementing targeted policy interventions.

Indexed as

Occupational DiseasesOccupational ExposureAdultBiomarkersCross-Sectional StudiesFemaleHumansIndiaMaleMiddle AgedWorking ConditionsBiomarkersbeedi rollinginformal sectormusculoskeletal disordersoccupational healthtobacco exposureurinary cotinine

Identifiers

PMID42136610
PMCPMC13168034

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.