SynthesisThe Journal of international medical research2026
Effectiveness of adjunctive interventions in patients undergoing rapid maxillary expansion: An umbrella review.
Synthesis in The Journal of international medical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BackgroundRapid maxillary expansion is widely used to correct transverse maxillary deficiency; however, its biological limitations have led to the use of adjunctive interventions, with inconsistent evidence regarding their effectiveness.ObjectiveThis umbrella review aimed to evaluate the effectiveness of adjunctive interventions, including low-level laser therapy, platelet-rich plasma, and erbium-doped yttrium aluminum garnet laser-assisted osteoperforations, in patients undergoing rapid maxillary expansion and identify the best available evidence among conflicting systematic reviews.MethodsOnly systematic reviews and/or meta-analyses were included, while primary clinical studies (randomized controlled trials and non-randomized controlled trials) were excluded. The methodological quality of each review was evaluated utilizing the A Measurement Tool to Assess Systematic Reviews-2. The Jadad decision algorithm was employed to determine the best available evidence among the conflicting reviews.ResultsFive systematic reviews met the inclusion criteria. Low-level laser therapy demonstrated a significant improvement in osteodensity after 2 months; however, no significant differences were observed at 1 and 3 months. Evidence regarding osteoperforations and platelet-rich plasma remained limited and inconclusive.ConclusionBased on the currently available data, low-level laser therapy offers limited benefits for transverse maxillary expansion, with minimal effects on bone consolidation appearing after 3 months. The effectiveness of osteoperforations with rapid maxillary expansion is uncertain, and evidence for platelet-rich plasma as an adjunct therapy is lacking.
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