Trial reportEndocrine, metabolic & immune disorders drug targets2026
Evaluation of the Effectiveness of Hyodine on Healing of Diabetic Foot Ulcer: A Randomized Single-Blind Controlled Trial.
Trial report in Endocrine, metabolic & immune disorders drug targets, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
introductionDiabetic foot ulcers (DFUs) pose a significant global health threat. It is estimated that individuals with diabetes have a 15-34% lifetime risk of developing a foot ulcer. This clinical study evaluates the comparative effectiveness of Hyodine solution versus standard treatment protocols in promoting the healing of DFUs.
methodsThis prospective, multicenter, single-blind randomized clinical trial enrolled 98 patients with type 1 and 2 diabetes who presented with grade 1-2 infected diabetic foot ulcers from participating diabetes clinics between June 2023 and January 2025. Patients were randomly divided into two groups by block randomization in a 4:1 ratio: a control group that received standard treatment and an intervention group (Hyodine) that received standard treatment plus an iodine solution. Wound cultures were obtained three times during the study: at baseline (before treatment initiation), week 2, and week 4. The collected data were analyzed using SPSS 20 software.
resultsIn our study, 98 patients with diabetic foot ulcers participated. Intervention group (n = 49): received Hyodine treatment, and the control group (n = 49) received standard wound care, for four weeks. The average age of the participants was 60 ± 11.46 years. Among the participants, 30 patients (30.6%) were females, and 63.3% of the individuals had a history of diabetic foot ulcer. The colony counts significantly decreased by the end of the study compared to the beginning of the study (P<0.001) in the intervention group. The difference in wound area in the Hyodine group between the first and last visits was statistically significant (P < 0.05). DISCUSSION: These results align with growing evidence that hyaluronic acid-based treatments, such as Hyodine, enhance antimicrobial activity and accelerate wound healing in chronic diabetic foot ulcers.
conclusionTo reduce complications from diabetic foot ulcers, the implementation of advanced therapeutic interventions is critical for alleviating the burden on both patients and healthcare systems. CLINICAL TRIAL NUMBER: IRCT20088094001199N8.
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