Evidence map›Paper›PMID 42136383›Full record

ArticleTherapeutic advances in respiratory disease

Development of a clinical prediction model for cough variant asthma.

Haodong Bai, Baiyi Yi, Tongyangzi Zhang, Yiqing Zhu, Wanzhen Li, Shengyuan Wang, Xianghuai Xu, Li Yu

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Article in Therapeutic advances in respiratory disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

8 authors.

Haodong BaiDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Baiyi YiDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Tongyangzi ZhangDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Yiqing ZhuDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Wanzhen LiDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.ORCID 0000-0002-9980-7933
Shengyuan WangDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.ORCID 0000-0003-1245-2998
Xianghuai XuDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, 389 Xincun Road, Shanghai 200065, China.ORCID 0000-0002-8713-5332
Li YuDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, 389 Xincun Road, Shanghai 200065, China.ORCID 0000-0002-1054-017X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCough variant asthma (CVA) is a common cause of chronic cough but remains underdiagnosed due to limited access to bronchial provocation test.

objectiveTo develop a clinical prediction model for CVA based on more accessible indicators.

designA single-center retrospective cohort study.

methodsA retrospective cohort of patients with chronic cough from January 2024 to December 2024 was included. The patients were randomly divided into a training set and an internal validation set at a ratio of 7:3. Univariable and multivariable logistic regression analyses were used to identify independent predictors of CVA. A nomogram prediction model was constructed based on these factors. The predictive performance of the nomogram was evaluated using receiver operating characteristic (ROC) curves, calibration curves, and decision curve analysis (DCA).

resultsA total of 323 patients with chronic cough were included, with 226 assigned to the training set (45 with CVA, 181 with non-CVA) and 97 to the internal validation set (23 with CVA, 74 with non-CVA). Multivariable logistic regression analysis identified increased eosinophils in induced sputum, elevated peripheral blood eosinophil count (PBEC), raised FeNO

conclusionThe CVA clinical prediction model based on induced sputum cytology, PBEC, FeNO

Indexed as

AsthmaCoughCough-Variant AsthmaNomogramsAdultBronchial Provocation TestsChronic CoughEosinophilsFemaleHumansLogistic ModelsMaleMiddle AgedPrediction AlgorithmsPredictive Value of TestsRetrospective Studieschronic coughcough variant asthmaprediction model

Identifiers

PMID42136383
PMCPMC13180199

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.