Superior Induction of Apoptosis by Blue Light Compared to Red Light Photodynamic Therapy in Cutaneous Squamous Cell Carcinoma Keratinocytes.

Julia Stolyar, Margaret Kabakova, Paras Patel, Julie Saadia-Hazkour, Evan Austin, Jared Jagdeo

Abstract readComparative Study

In one paragraph

Article in Journal of biophotonics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Julia StolyarDepartment of Dermatology, State University of New York, Downstate Health Sciences University, Brooklyn, New York, USA.

Margaret KabakovaDepartment of Dermatology, State University of New York, Downstate Health Sciences University, Brooklyn, New York, USA.

Paras PatelRowan University School of Osteopathic Medicine, Stratford, New Jersey, USA.

Julie Saadia-HazkourDepartment of Dermatology, State University of New York, Downstate Health Sciences University, Brooklyn, New York, USA.

Evan AustinDepartment of Dermatology, State University of New York, Downstate Health Sciences University, Brooklyn, New York, USA.

Jared JagdeoDepartment of Dermatology, State University of New York, Downstate Health Sciences University, Brooklyn, New York, USA.

Funding

Sun Pharma

6 · The paper itself

Abstract

This study compared apoptosis induction in squamous cell carcinoma keratinocytes following exposure to 5-aminolevulinic acid combined with either blue light (417 ± 5 nm) or red light (635 ± 5 nm) photodynamic therapy, with apoptotic activity quantified via levels of Annexin V expression. Our results demonstrated that blue light induces superior levels of apoptosis in squamous cell carcinoma keratinocytes compared to red light at the parameters tested. Both wavelengths demonstrate additional dose- and temperature-dependent effects across two squamous cell carcinoma cell lines. These conclusions had significant implications for the clinical selection of a light source in combination with 5-aminolevulinic acid photodynamic therapy in the treatment of actinic keratosis and early squamous cell carcinoma lesions.

Indexed as

ApoptosisBlue LightCarcinoma, Squamous CellKeratinocytesPhotochemotherapySkin NeoplasmsAminolevulinic AcidCell Line, TumorCutaneous Squamous Cell CarcinomaHumansRed LightAminolevulinic Acidactinic keratosisblue lightphotodynamic therapyred lightsquamous cell carcinoma

Identifiers

PMID42136364

DOI10.1002/jbio.70272

PMCPMC13176894

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.