Evidence map›Paper›PMID 42136225›Full record

ArticleAnatomy & cell biology2026

Anticancer activity of Hebesu extracts in cancer cell lines.

Eun-Jung Kim, Sohyun Kim, Nayeon Bak, Senthil Kumar Baskaran, Suyeon Lee, Junsu Kim, Masahito Uchiyama, Jong-Min Lee, Han-Sung Jung

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Anatomy & cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Eun-Jung KimDivision in Anatomy and Developmental Biology, Department of Oral Biology, Taste Research Center, Oral Science Research Center, BK21 FOUR Project, Yonsei University College of Dentistry, Seoul, Korea.ORCID https://orcid.org/0000-0002-9515-7590
Sohyun KimDivision in Anatomy and Developmental Biology, Department of Oral Biology, Taste Research Center, Oral Science Research Center, BK21 FOUR Project, Yonsei University College of Dentistry, Seoul, Korea.ORCID https://orcid.org/0009-0009-1510-018X
Nayeon BakDivision in Anatomy and Developmental Biology, Department of Oral Biology, Taste Research Center, Oral Science Research Center, BK21 FOUR Project, Yonsei University College of Dentistry, Seoul, Korea.ORCID https://orcid.org/0009-0005-3820-8290
Senthil Kumar BaskaranDivision in Anatomy and Developmental Biology, Department of Oral Biology, Taste Research Center, Oral Science Research Center, BK21 FOUR Project, Yonsei University College of Dentistry, Seoul, Korea.ORCID https://orcid.org/0009-0008-8158-6731
Suyeon LeeDivision in Anatomy and Developmental Biology, Department of Oral Biology, Taste Research Center, Oral Science Research Center, BK21 FOUR Project, Yonsei University College of Dentistry, Seoul, Korea.ORCID https://orcid.org/0009-0005-6313-8554
Junsu KimDivision in Anatomy and Developmental Biology, Department of Oral Biology, Taste Research Center, Oral Science Research Center, BK21 FOUR Project, Yonsei University College of Dentistry, Seoul, Korea.ORCID https://orcid.org/0009-0001-2268-5157
Masahito UchiyamaUchiyama Group, Hyuga, Japan.ORCID https://orcid.org/0009-0006-8109-4046
Jong-Min LeeDivision in Anatomy and Developmental Biology, Department of Oral Biology, Taste Research Center, Oral Science Research Center, BK21 FOUR Project, Yonsei University College of Dentistry, Seoul, Korea.ORCID https://orcid.org/0000-0002-9466-7644
Han-Sung JungDivision in Anatomy and Developmental Biology, Department of Oral Biology, Taste Research Center, Oral Science Research Center, BK21 FOUR Project, Yonsei University College of Dentistry, Seoul, Korea.ORCID https://orcid.org/0000-0003-2795-531X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hebesu, a small citrus fruit from Miyazaki, Japan, has the potential to advance anticancer activity due to its high content of bioactive flavonoids, including narirutin, naringin, hesperidin, and neohesperidin. This study explored the anticancer effects of Hebesu extract (HBS) in various human cancer cell lines: MDA-MB-231 (breast cancer), HepG2 (liver cancer), and A549 (lung cancer). The results showed that treatment with HBS led to a substantial reduction in cell viability in a dose-dependent manner and induced morphological changes, accompanied by increased expression of apoptosis-related markers. TdTomato fluorescence imaging demonstrated that cytotoxicity in breast cancer cells was dependent on both the concentration and duration of exposure. Furthermore, HBS reduced

Indexed as

Breast neoplasmsCell lineHebesu extractsLiver neoplasmsLung neoplasms

Identifiers

PMID42136225
PMCPMC13616755

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.