ReviewNeural plasticity2026
Metabotropic Glutamate Receptor-Dependent Synaptic Plasticity in Age-Related Neurodegenerative Disorders.
Review in Neural plasticity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Review
- Metabotropic Glutamate Receptor-Dependent Synaptic Plasticity in Age-Related Neurodegenerative Disorders.Neural plasticity · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Synaptic plasticity is a fundamental property of the nervous system that underpins learning, memory, and adaptive behavior across the lifespan. Disruption of plasticity mechanisms is increasingly recognized as a unifying feature of age-related neurodegenerative and neuropsychiatric disorders. While classical models of long-term potentiation (LTP) and long-term depression (LTD) have primarily emphasized ionotropic glutamate receptors (iGluRs), emerging evidence identifies metabotropic glutamate receptors (mGluRs) as central regulators of synaptic stability, metaplasticity, and activity-dependent translational control. This review synthesizes molecular, synaptic, circuit-level, and translational evidence to position mGluR-dependent plasticity as a context-sensitive signaling framework that governs excitatory-inhibitory balance across cortical and subcortical networks. This review examines subtype-specific contributions of Groups I, II, and III mGluRs to LTP and LTD, highlighting their roles in intracellular calcium dynamics, protein synthesis-dependent plasticity, and neuron-glia interactions. Particular emphasis is placed on receptor localization, intracellular signaling pathways, and region-specific cortical plasticity, which collectively determine how mGluR signaling shapes functional outcomes across distributed brain circuits. This review further discusses how dysregulation of mGluR-mediated plasticity contributes to synaptic and circuit dysfunction in Alzheimer's disease (AD), Parkinson's disease (PD), schizophrenia, autism spectrum disorder (ASD), Fragile X syndrome (FXS), and epilepsy, with attention to disease stage-specific and context-dependent alterations revealed by electrophysiological, molecular, and receptor imaging studies. Finally, emerging translational strategies, including subtype-selective biomarkers, allosteric and pathway-biased modulation, and circuit-targeted interventions, are evaluated for their potential to restore adaptive plasticity while limiting maladaptive network remodeling. Collectively, this review reframes mGluR-dependent synaptic plasticity as a dynamic and integrative regulator of neuronal circuit function in aging and disease, providing a conceptual and mechanistic foundation for the development of precision neuroplasticity-based therapeutics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.