Evidence map›Paper›PMID 42135869›Full record

ArticleActa neuropathologica communications2026

Investigation of the myelin-amyloid interplay in Alzheimer's disease: insights from novel dsCMA imaging in mouse and human brains.

Hanpeng Xu, Sumit Nanda, Jiandong Sun, Mitchell Rudd, Lin Gou, Haley Marks, Christopher K Williams, Shino Magaki, Harry V Vinters, Houri Hintiryan and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hanpeng XuBrain Research and Artificial Intelligence Nexus (B.R.A.I.N.), Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Sumit NandaBrain Research and Artificial Intelligence Nexus (B.R.A.I.N.), Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Jiandong SunBrain Research and Artificial Intelligence Nexus (B.R.A.I.N.), Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Mitchell RuddBrain Research and Artificial Intelligence Nexus (B.R.A.I.N.), Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Lin GouBrain Research and Artificial Intelligence Nexus (B.R.A.I.N.), Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Haley MarksCalifornia NanoSystems Institute (CNSI), University of California Los Angeles, Los Angeles, CA, USA.
Christopher K WilliamsDepartment of UCLA Pathology and Laboratory Medicine, Ronald Reagan UCLA Medical Center, University of California Los Angeles, Los Angeles, CA, USA.
Shino MagakiDepartment of UCLA Pathology and Laboratory Medicine, Ronald Reagan UCLA Medical Center, University of California Los Angeles, Los Angeles, CA, USA.
Harry V VintersDepartment of UCLA Pathology and Laboratory Medicine, Ronald Reagan UCLA Medical Center, University of California Los Angeles, Los Angeles, CA, USA.
Houri HintiryanBrain Research and Artificial Intelligence Nexus (B.R.A.I.N.), Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Hong-Wei DongBrain Research and Artificial Intelligence Nexus (B.R.A.I.N.), Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA. HongWeiD@mednet.ucla.edu.

Funding

Mapping Cellular Resolution Connectopathies in Aging and Alzheimer's DiseaseU01AG076804 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Hong-Wei Dong, Bruce T Lamb · 2022 to 2026
$14.3M
Sexual dimorphic cell type and connectivity atlases of the aging and AD mouse brainsR01AG084036 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Hong-Wei Dong · 2023 to 2026
$6.2M
Multiphoton Microscope for Deep Tissue ImagingS10OD025017 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BENTOLILA, LAURENT A. · 2018 to 2018
$599k
National Science Foundation CHE-0722519NIA NIH HHS R01 AG084036NIA NIH HHS U01 AG076804NIH HHS R01AG084036-01 (H.-W.D.)NIH HHS S10 OD025017NIH HHS S10OD025017
6 · The paper itself

Abstract

Myelin deterioration impairs neural communication and may contribute to neurodegenerative diseases such as Alzheimer's disease (AD). However, the spatiotemporal relationship between myelin degeneration and AD pathology remains unclear. We developed a novel imaging method-double-scan Cyto- and myelo-architecture (dsCMA)-that integrates multi-fluorescent labeling of cytoarchitecture and pathological markers with brightfield myelin staining on the same tissue sections. Coupled with computational tools for automated detection and quantification of amyloid-beta (Aβ) plaques and myelinated axons, dsCMA enables systematic analysis of Aβ-myelin interactions in 5xFAD mice and postmortem human AD tissues. In mice, we identified progressive, region-specific myelin disruption associated with Aβ accumulation, particularly in the hippocampus and cortex. Human samples revealed variable Aβ-myelin spatial relationships across individuals and regions, with evidence supporting a potential myelin origin for some plaques. These findings offer new insights into Aβ-myelin interplay and establish dsCMA as a scalable platform for histopathological analysis in translational and longitudinal AD research.

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesBrainMyelin SheathPlaque, AmyloidAgedAged, 80 and overAnimalsDisease Models, AnimalFemaleHumansMaleMiceMice, TransgenicAmyloid beta-Peptides

Identifiers

PMID42135869
PMCPMC13348811

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.