ArticleJournal of cardiothoracic surgery2026
Streamlining the workflow: evaluation of ECG-gated computed tomography as a comprehensive imaging modality prior to intervention for mitral valve regurgitation.
Article in Journal of cardiothoracic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundECG-gated computed tomography (CT) is not commonly utilized as the primary imaging modality for the diagnosis and management of degenerative mitral valve (MV) disease and preparation for MV intervention typically involves the use of several imaging studies. We hypothesized that CT can accurately identify MV pathology and exclude obstructive coronary artery disease (CAD) in this population potentially obviating the need for routine use of additional imaging modalities.
methodsCT was compared to invasive coronary angiography (ICA), transthoracic (TTE) and transesophageal (TEE) echocardiography for identification of coronary artery patency and mitral valve pathology respectively in patients undergoing MV evaluation between January 1, 2019, and December 31, 2023.
results240 patients underwent TTE, TEE, and CT for mitral valve evaluation prior to intervention. Agreement was moderate when CT was compared to TTE for identifying prolapse (71%) and poor for flail segments (51%), with CT being superior. Compared to TEE, CT showed 96% agreement for prolapse (sensitivity 96.5%, CI 92.5-98.7% and specificity 82.3%, CI 71.2-90.5%) and 83% agreement for flail segments (sensitivity 75%, CI 67.8-81.8% and specificity 90.8%, CI 81.9-96.2%). Cohen's κ statistic was 0.81 and 0.65 for prolapse and flail respectively. 215 patients underwent ICA and CT evaluation followed by valve intervention. CAD prevalence was low at 6.0%. Compared to ICA, CT was 83.3% sensitive (CI 58.6-96.4%) and 97.9% specific (CI 94.9-99.4%) for CAD with excellent agreement (Cohen's κ = 0.81).
conclusionAs compared to TEE, CT has excellent sensitivity and specificity for diagnosing prolapse and good agreement for flail segments. CT also shows strong agreement with ICA in evaluating CAD. CT provides a non-invasive alternative to TEE and ICA to accurately identify MV pathology and exclude significant CAD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.