Evidence map›Paper›PMID 42135772›Full record

ReviewClinical epigenetics2026

Sperm tRNA-derived fragments: molecular mechanisms and clinical implications for paternal epigenetic inheritance.

Shiwei Song, Bin Zhang, Fengli Xiong, Mengkun Li, Lingqi Liu, DongDong Meng, Changfeng Yang, Fulin Ma, Haizhong Xu, Dehui Chang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinical epigenetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shiwei Song *Department of Medicine, Northwest Minzu University, Lanzhou, Gansu, 730050, China.
Bin Zhang *Department of Medicine, Northwest Minzu University, Lanzhou, Gansu, 730050, China.
Fengli Xiong *Department of Medicine, Northwest Minzu University, Lanzhou, Gansu, 730050, China.
Mengkun Li *Department of Medicine, Northwest Minzu University, Lanzhou, Gansu, 730050, China.
Lingqi Liu *Department of Medicine, Northwest Minzu University, Lanzhou, Gansu, 730050, China.
DongDong Meng *Department of Medicine, Northwest Minzu University, Lanzhou, Gansu, 730050, China.
Changfeng Yang *First School of Clinical Medicine, Gansu University of Chinese Medicine, Lanzhou, 730000, China.
Fulin MaFirst School of Clinical Medicine, Gansu University of Chinese Medicine, Lanzhou, 730000, China.
Haizhong XuFirst School of Clinical Medicine, Gansu University of Chinese Medicine, Lanzhou, 730000, China.
Dehui ChangDepartment of Medicine, Northwest Minzu University, Lanzhou, Gansu, 730050, China. 13341278504@163.com.

Funding

Central University Research Fund of Northwest Minzu University 31920240072Central University Research Fund of Northwest Minzu University 31920260109Central University Research Fund of Northwest Minzu University TS2024421Natural Science Foundation of Gansu Province 22JR5RA001Natural Science Foundation of Gansu Province 22KYLL195Natural Science Foundation of Gansu Province 23JRRA001Natural Science Foundation of Gansu Province 23JRRA531
6 · The paper itself

Abstract

Sperm tRNA-derived fragments (tRFs) have emerged as novel regulators of paternal epigenetic inheritance. By modulating embryonic epigenetic reprogramming, transposon silencing, and intergenerational genetic programming, tRFs mediate the transgenerational transmission of paternal environmental information, extending conventional notions of genetic inheritance. This review systematically elaborates the molecular mechanisms, clinical applications, and potential interventional strategies of tRFs. Through an in-depth analysis of how tRFs regulate the epigenetic landscape during embryonic development, we highlight their applications in diagnosing and treating male infertility, as well as in preventing transgenerational diseases. This work provides new insights into interventions targeting paternal epigenetic transmission and associated disorders.

Indexed as

Epigenesis, GeneticPaternal InheritanceRNA, TransferSpermatozoaDNA MethylationEpigenetic MemoryHumansInfertility, MaleMaleRNA, TransferBiomarkerEmbryonic reprogrammingPaternal epigeneticsTransgenerational inheritanceTransposon silencingtRNA-derived fragments

Identifiers

PMID42135772
PMCPMC13445796

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.